If you aren't in a big hurry, want almost zero traffic, and smoother roads, take exit 33 then grab Hwy 15/17A, follow 15 until Santee where you need to jump back on the I95 to cross the lake. On the north side of the lake, take the first exit to Hwy 301 which can be followed to the state line at South of the Border. You will have to deal with 55mph speed limit and about two dozen traffic lights, but not bad.
If you want to avoid most of the traffic lights and traffic, avoid Florence though you never get downtown or heavy traffic by taking Hwy 56 in Turbeville over to I95.