SW Missouri to Lake Superior. Best route?

This persons high points are spot on. I've seen most of these and they are worth seeing! (post above mine)
Brian

If you have the time, I would head to Dubuque via hwy 151 out of cedar rapids. I live in Branson and its about a 8 hours drive to Cedar Rapids via 44.54.19,H at center H is a great Ozark road. then 24 to 218 and to cedar rapids. At Dubuque the Mississippi River Museum https://www.rivermuseum.com is well worth stopping at. There is also the Cog Railway Elevator that's a must to see.

On our way to Madison via 151 there's the House on the Rock built by Frank Loyd Wright. North of Madison is the Baraboo Circus Museum www.circusworldbaraboo.org and then do not forget Wisconsin Dells, Its a different version of Branson.

From Madison then head up to Michagan, its really a great spot. One has to try the "Pasties" they are great eats.

I'm a little farther SW of you. I've traveled that route and it's ok, but my preference personally is to head north to Des Moines, east on I-80 to Davenport, north on US62 to Dubuque, and US151 to Fond du Lac, then US41 north. Past Marinette I'd suggest M-37 along the shore for an occasional view of Lake Michigan. The reason for my preference is twofold: less traffic congestion out west, and I think the US151 stretch from Dubuque to Madison is scenic.

I hear there is an antique vehicle museum at Walcott IA... been meaning to stop there sometime myself. Here is a page or three with that museum plus some of the more unusual sights in Iowa. https://www.atlasobscura.com/things-to-do/iowa/places
Also this list of places along I-80:
https://www.buddythetravelingmonkey.com/things-to-do-in-eastern-iowa-along-i-80/

I-44 to I-55 at St. Louis to I-39 at Bloomington/Normal? That's how I would go.