I live in Florida and we spend time traveling between Orlando & St. Louis. I also agree with refueling outside Memphis as their are several places to stop that can handle your coach. We do not use Interstates unless it is necessary for short travel.You can follow I-55 south to Winona, MS then east on US 82 to Alt. US 45 south to Meridian, MS. Take I-20 east to US 80 to Montgomery. Pick up US 231 south. We use US 231 between I-10 and Montgomery. US 231 is all four lane and good road. When you get to I-10 follow it to US 19 at exit 225. US 19 is four lane road and will take you to Perry, FL. Pick up US 98 south out of Perry to Chiefland, FL. Take Alt. US 27 from Chiefland to your destination in Willison . All good road with minor traffic. Plenty of places along the way to refuel.