We take I-88 to I-81 every January on our way south and have never had a weather issue on the northern end that affected road conditions. We do pay attention to the weather forecasts before starting out, and adjust as needed. Only once have we stayed an extra day somewhere to wait out a storm so far, and that was in southern VA to avoid icy roads on I-77 in NC. We always include enough "flex time" in our travel plan to allow for unexpected delays while still meeting reservation deadlines on the other end.