Prince George to Edmonton can be done in one long day of driving but as you are pulling a 5th, wheel, it is better to split into 2 days.
The drive through Mount Robson Provincial Park and Jasper National Park is scenic and there are plenty of places to pull over for photo ops and rest areas for washroom breaks etc.
If you are wanting to stay overnight in any of the parks, and depending on the day of week, reservations are strongly recommended. Alternatively, leaving Prince George, you can drive about 2.5 hours east to McBride, spend the night there, then drive through to Edmonton the next day.
As for the road itself, it is generally in good condition and like many northern roads, summer road re-construction is common.
Finally, you may want to ask the Forum MOD to move this to the RVing in Canada forum as you will find a lot more helpful info there.