we just came from there after a 10 day visit. we have been there 5 times and Love it!
Most of the things to see are on the western side, so we stay in Study Butte/Terlingua at the Big Bend resort. Just don't expect a real resort.
ideas:
Be sure to eat at Starlight Theatre- great food, live music, happy hour= $1 tacos and $2 Margaritas.
take the Ross Maxwel scenic Dr.
visit the hot springs. its easier to wear your suit, as there isn't a great place to change.
the spring is right next to the rio grande. really neat.
short hike- Chisos Basin loop trail
This time we went across the border to Boquillas and had a great time. that was yesterday. I havent even blogged about it yet but here are the rest of my Big Bend posts.
Big BendIf you have any specific questions let me know.