We were in that area this September and had a wonderful time.
Grand Junction/Fruita is great. We stayed at the James Robb State Park Fruita Campground, excellent CG, very convenient for the marvelous Colorado National Monument for red rock scenery.. Don't miss it! There are also wonderful wineries near there you can tour. The Grand Mesa is a climb but has many campgrounds and lots of vistas.
Black Canyon of the Gunnison NP is also excellent - has a good campground with electric hookups. Montrose has a nice farmer's market on Saturday for produce. Also every kind of chain store you might want south of town.
We had fun in Ouray at the 4J+1 campground in a site by the river, walking distance to the town and a very interesting box canyon. Go to Mouse Chocolates and have coffee and "scrap cookies." There's a neat old western hotel close to the CG with a "face on the bar room floor."
We drove the San Juan Skyway to Telluride and south - beautiful scenery! Snow on the upper elevations.
We spent some time around Delores at the Anasazi Heritage Center and Canyon of the Ancients if you like ancestral Puebloan ruins. Stayed at McPhee Reservoir (COE or BLM.) Crow Canyon Archeological Center has an excellent one-day seminar you can take on that subject, with a visit to a dig. Mesa Verde has a new visitors center at the base entrance, instead of up on the Mesa.