plan ahead, use the computer radar programs.. keep an eye on snow storms and ICE...
and do not depart 12 hours before storm arrives at your departure location.. that is a bad plan.
but driving in snow with a trailer or 5th wheel is not that big of a deal.. maintain a steady speed... and NO quick movements..
have several motel numbers ready, over many exits... time & speed will very a lot..
last November. 800 mile trip. planed 400 over 2 days.. first 400 took 15 hours. and it was just Rain and 42 degrees. lots of accidents. ( West Virginia, Virginia )