AH GAN.
Depending on the weather I would do I81 to Binghamton, I 86 to I90 in PA. This avoids the tolls on the Thruway. I90 to I271 to I71 to avoid Cleveland. I71 to Louisville, KY. When you get to Louisville you should be above freezing temps 24/7 average. Then get on I65 south. At Elizabeth, KY you have to choose. The Western Kentucky Parkway to Memphis or I 65S to Nashville.
I prefer Nashville so I usually go that way. Do what you want in Nashville then get on the Natchez trace to Natchez, MS. Free CG's on the route which is open to cars and RV's but no commercial vehicles. No hookups but quiet. In Natchez you can dump and fill at the tourist information center. There is also a nice CG across the river that overlooks the Mississippi.
From there head to Alexandria, LA and then to I10 but I usually head to the gulf and follow LA 82 to TX 89 to Galveston VIA 2 ferries. Then I follow the coast to Surfside Beach, TX. Spend a night or 2 at the Galveston Island State Park. Water and Electric with Dump station
I eventually wind up on I10 to Lordsburg, NM and get on US 70 to Globe then US 60 to Phoenix, AZ
I do lots of side trips on the way but this is my direct route.
gone to FREDERICKSBURG, TX for the German Food, Stopped in San Antonio,
If I go to Memphis I get on I55 and get to I10 to Lafayette, LA I then head for the Gulf road LA 82
I am not fond of the Pennsylvania mountains in November