You are the only one that can decide if it is worth it. I would think the biggest Pro is no more cold winters and snow shoveling. Which I think is tops on most snowbirders list. The big question that you need to address is whether you can adjust to living in a small space for several months at a time.
We have a 32' Class C motorhome and have no problems camping for the weekend or even a week or two at a time. However, it is very different when we live in the camper for 4 months. After the first few weeks, the size limitation becomes very apparent.
With your Truck, you will probably only be able to tow smaller trailers, maybe 26' at the longest. Even with slide outs, that's less than 200 square feet of living space. If you expect to spend most of your day indoors, that could become an issue. Before you jump head first into the life style, it might not be a bad idea to find a campground close to home where you can spend a month living in the camper. If you can do a month, then you can probably do the full season.
Every snow bird is different. A lot head south right after Christmas and get home before Easter. Some head south for a couple months, some spend 6 months down south and 6 months at home. We spend our summers in the north and live in the south. We generally go from May 1 to after Labor Day. If it were up to me, I'd spend 5 months up north May 1 to October 1, but the wife and kids are ready to get back home sooner.
-Michael