We have taken 219 (from Buffalo) a few times when we wanted a leisurely drive. Even though it is the shortest route it will take hours longer. You will pass through many small towns and at times the road is quite hilly & winding with narrow or no shoulders. I would not take it in the winter months. We have been driving to FL at least twice a year from near Barrie ON and have been taking the I-79,SR-19,I-77-26-95 route since it was completed nearly 40 years ago.
As previously mentioned there are some pretty big hills (one is 7 miles long on I-77 in VA) through the mountains in WV & VA and the roads are not always cleared well or right away.
If you must travel at that time of year and especially if towing an RV I'd take I-75 or even I-65 for a flatter run even though they are a few miles longer.
We are currently in FL and will be driving home in the middle of November. Even though we are in a car this trip, Hubby is considering taking I-75 home to avoid any bad road conditions.
~Diane