Just watch the long range weather forecasts for the area that you will be travelling through. Snow, high winds etc. and temperature. We have always used the antifreeze in toilet etc, no water until far enough south for warm temps, usually after the second night. The last trip we stayed in an "open" KOA in Ohio, but it was a mere parking spot with electricity. The morning temp was -29F, we used a lot of propane and electric heaters and just barely comfortable. On after thought we should have stayed in a motel.
We are comfortable in the RV at 0F, but would definitely stay in a motel at -29f.
Ken