We ALWAYS drove our Class C (and then a 5er for a couple of years), from Michigan down to FL in February. We'd usually watch the weather for a spate of mild weather, then head out; but sometimes you don't have that luxury. There's always the thought that you're subjecting your RV to road salt as you travel through the snowy states - but I'm not sure that subjecting your RV to months of Florida's sun (if you stored it), is any less damaging?
One year, we drove through an incredible ice storm in Tennessee - there were inches of ice on the roads. The Class C just rolled along - it handled better than a car, IMO. And we managed to get caught in the Great Atlanta Ice Storm of 2013 (apparently Georgia has never heard of road salt) and drove 40 miles of the slickest Black Ice I've ever seen - our 2-wheel drive pickup did fine with the weight of the 5er on the back. WE had no problems, but dodging the panicked locals who were careening out of control, was another matter....LOL! And I remember another year of 35-mph blizzard-like conditions in N Ohio; and the Class C just busted through the drifted snow. No drama - we sat high enough to see over the ground blizzard. I think the only conditions that would make us stay off the road would be high winds AND ice.