Where should we go & what should we see?

Ditto the Biltmore. Amazing place! Well worth the time.

Other must-sees, IMO: Gettysburg (allow a full day also), and - if anyone in the family is into horses - Kentucky Horse Park and Old Friends Farm in the Lexington area. Nice CG at KY Horse Park too, makes a good base camp for the area.

Around Lexington, KY you can visit Kentucky Horse Park. In fact, the campground next to the horse park is excellent, but water & electric only. If you like horses Keeneland Race Course is a nice visit (they race in April & October only). Churchill Downs in Louisville has the Kentucky Derby Museum right next to the track. It's a fun museum.

Maker's Mark Distillery just south of Bardstown, KY is a nice visit. It's actually located in Loretto, KY.

In the Smoky Mountain area of North Carolina, US 64, just east of Highlands, has several awesome waterfalls right near the road. It has been awhile since I've been over that way, but those waterfalls are what I remember best.

Oh yeah, do your research for the Smoky Mountains area, there is just too much to do to list. The park itself is a no misser and if you can stay at Elkmont campground do so. No full hook ups tho. Otherwise there are a lot of nice CGs in the area. While in the park a hike up to Clingmans Dome is spectacular if your able. I also enjoy Ripleys Aquarium in Gatlinburg. This area can get crazy busy too depending on time of year. Be prepared for bumper to bumper traffic.

Unless you all are real cavers, one day at Mammoth is enough. Get off the main roads when in Ohio and stop at some of the homes that sell things like baskets, or hand made furniture. It is a great area to visit. We just did KY and TN. Lots of bourbon in KY, one or two distilleries is plenty unless you are a true bourbon drinker. Woodford reserve is probably the most beautiful tour to take. Visit downtown Louisville for the Louisville Slugger factory, Churchill downs. Lexington has some great horse farms to see. Once again get off the main roads and see what is out there.

If you have never seen the Biltmore house......you should. It can take the whole day to do the house, gardens and winery. Wife and I have been there several times and always enjoy it. It is a bit pricey at 69 bucks a ticket, then throw in a meal or 2 and a case of wine to bring home and wow. They do offer a discount if you buy tickets online tho. Check their web site.... Biltmore.com.

Asheville is nice. Biltmore estates. Lookup Campfire Lodgings for a nice well kept campground. Close to the parkway and few good local places to eat.

Sounds like a great trip. I don't know your exact route but here's what I do when planning our treks.

I would use mapquest.com and see where we would end up after 200-300 miles. Then I would use woodalls.com and http://www.allstays.com/Campgrounds/ to locate a campground.

Once I know where I am stopping I'd check the local chamber of commerce sites for those towns. Have found some hidden gems in those c of c sites including bluegrass festivals, ethnic festivals and some little known natural wonders. I'll also use tripadvisor.com for reviews and side trip ideas.

We aren't shoppers but we always stop at Lehmans Non Electric store in Dalton OH. They have great stuff that can be used for camping. https://www.lehmans.com/default.aspx

Mammouth Cave is a must see. Figure a couple of days to take the tours.

Take the Blue Ridge Parkway back up north when you are done.