We decided on a fifth wheel because:
1) The have a lot more room inside
2) They have a lot of basement storage space.
3) We did not need a toad, which means you only have one engine and other systems to maintain not two.
I'm guessing that a fifth wheel may be a bit harder to maneuver into tight spaces than a class C.
But as others have pointed out, you are going to have limited space in just about any RV compared to a house. There are really big fifth wheels tho, 45 feet long or longer, but I wouldn't even think of pulling one.