I am assuming you meant to say two 6VDC Batteries in series and two 12VDC batteries in parallel... Consider these pictorials
Typical wiring for both battery groups
Two 6VDC batteries in SERIES - Connecting two in series doubles the OUTPUT DC OUTPUT VOLTAGE - The RESERVE POWER will only be the same as ONE 6VDC Battery.
Two 12VDC Batteries in PARALLEL - Connecting the two in PARALLEL keeps the same DC OUTPUT VOL:TAGE - The RESERVE POWER will be doubled connecting these in parallel
It really comes down to cost. 6VDC 220AH batteries can be purchased from COSTCO/SAM CLUB for around $80 each. The Reserve Power for this battery is typically 440 minutes (7.3 Hours) meaning this group setup should produce 12VDC @25AMPS for around 3.6HR before dropping to 50% charge state.
The cost of 12VDC 220AH batteries is not going to be cheap. You can get a 12VDC 85AH Battery for around $80 most anywhere. The RESERVE POWER for a 12VDC 85AH battery is 140 minutes (2.3 Hours) meaning this battery group will only produce 12VDC @25 amps for around 1 hour before dropping to 50% state of charge. Having two in parallel will increase this to around 2 hours of time.
Hope this helps deciding which is better for you.
Roy Ken