I remember a 1/2 ton pickup pulling the space shuttle and said it would do it. CAN it? yes SHOULD it? probably not.
Each truck is spec'd differently and the setup of each fifth wheel is also different. Those need to be taken into account.
I had a 2012 Ford F-150 that I had spec'd and ordered. It had the 3.5 Eco-boost, the max tow package AND the Heavy Duty package. It had a higher payload than most SuperDuty F-250s that were on the lot when it was delivered. We did pull a fifth wheel with it - a 2008 Wildcat 32QBBS. It did great and we never lost power going up mountains, etc. It's dry weight was less than 9K.
We were limited in what we could take with us and when we wanted to upgrade the fifth wheel, we went with a larger truck.