2 comments.
1)See their crush youtube video. Strength is a non-issue.
2)Hook up complexity is easier, especially on a non-level grade. As for sight to hitch, its simple to see thru the back window, Ram cams make it even easier.
Like others, I have yet to see a "I had it, hated it!" comment anywhere. No.1 problem with 5th wheel towing by pickups is lack of payload. Thanks Andersen for that extra 150# back cause I skipped a heavy slider. I am a 2 time Andersen buyer and absolutely recommend their products without hesitation.