There was advice in another recent tire thread that with tandem axle trailers, you get extra stress on the tires when turning called "shear" that makes the tread want to come off. To fight against that, the trailer mounted tire ( with tandem axles)should be fully inflated. This applies to both ST and LT tires.
The same tire on a bus, not tandem axle, does not get shear stress so much, so it would be ok at PSI according to those load charts, same as we do with the back tires of the truck depending on how much is in the box.
So, IMO based on that, and where the Ds already have margin for their load carrying, it would be better to inflate them fully even when the weight doesn't require that much PSI, instead of putting Es on and running them below full PSI.
I think that means, if you really feel the need for Es, you should also get wheels that can take the 80 lbs and run them at 80.
Also I don't see much point in having the weight margin Es give you, when your axles won't take that much weight. Normally, your tires are the "weak link" and GAWR is based on the tires, with the axle being able to do more.
If you have two Dexter 5200s with Ds, your GAWR is 10,160 and the axles are 10,400. What good would Es do you? To take advantage of the Es you would want 7,000 axles.