We are a few hours away, but we are expecting snow again on Friday night and Saturday, changing to rain late in the day when it's SUPPOSED to get above 32 degrees. It's again supposed to snow on Sunday.
With that being said, the interstates should be kept in pretty good shape, but if it starts snowing hard and the traffic is light, snow will pile up on the interstates and there are some good size hills to traverse through and around. I-64 and I-77 are good roads with a max of 7% grades, but there are some on each of these roads, which haven't changed since you pulled on it the last time.
If it begins to snow in earnest, I would pull off and find someplace to veg for a while or overnight, if needed. Take lots of warm clothing and some supplemental heating, bottled water to flush with (who cares if the black tank freezes, it should have plenty of expansion room), and take the time that you need to arrive safely.