Not sure what brand AC you have, but I have had just about every leak issue you can have with my two AirXcel (Coleman Mach) ACs.
Old seal design problem: My 2012 unit had the old seals in it that were subject to severe compression under normal use. This can cause AC loosening and leaks around the seal, but in my case it just smashed the condensation water drain valves into the soft TPO roof and caused water buildup in the unit and leaks into the cabin. This leak, of course, happens without any rain event. Right around that time or the year before, Airxcel came out with a stiffer seal that would not compress over time as bad. They did not change part numbers unfortunately so you can get old stock even today. I called Airxcel directly to get the right parts and changed both of my AC seals. I have changed seals on several RVs and these were noticeable stiffer. Usually, you are tightening until the yellow tabs are level with the roof and when they get there you feel like the bolt is still too loose and you need to tighten more. With the new design seal, the bolts are much tighter when the proper level is reached.
Nose down problem: My forward AC is tilted with the nose down. On the model I have, a manufacturer is supposed to drill out the two front 3/8" drain holes in the metal pan when mounting nose down. My manufacturer did not, and during a rain storm water would build up until it water-falled over the pan lip into the cabin (yes, it was over the bed). I drilled them out and fixed the problem.