Other than considering cost, you might consider how you plan on using your rig. It always cost more to change your mind after the fact.
With a Motorhome,while traveling long distances,you can pull over and make some dinner, use the restroom relax a while never leaving the coach with the ac or heat running on a rainy or miserably cold day. Same with arriving at your final destination. Convenience is the key here.
However if you plan on traveling less, and staying put for long periods, a 5r and truck is the way to go. Especially if you have another use for the tow rig.
I would much rather have the motorhome option but my particular use fits a fiver better for the time being. Therefore the cost of maintenace and such dont matter. No matter which you choose, Rving is expensive.