Good responses, yes there is a minimal risk driving down the road, but it is probably less than the risk of you getting into an accident! There is one major issue not discussed, and what do you do when fueling? With class A and C it is relativley easy to turn off the fridge prior to pulling into the fuel stop, then turn it back on once underway, but in a fith wheel, you would have to come to a stop get out, go into the trailer and turn off the fridge. The proble, is more with the electronic lighters than with the propane, but one should be very careful around the gas "docks"!