Have to be aware of the height but not really an issue. In town I often have to drive in the left lane because of overhanging trees on the curb lane. When traveling smaller highways I check if there are any low clearance issues along the route. So far I've never found any highway I've wanted to travel that had any clearance issues. Might depend on where you live. Interstates are never a problem as truckers use them too.
Smaller campgrounds might have issues from trees but most often not a problem for campgrounds designed with RV's in mind. I've not had a problem although I've been to campgrounds where some spots might be tight but they're usually given to smaller trailers such as popups.