Over the last 3 decades we have normally filled our ST tires on our towables (TTs, 5er, toy hauler) to max psi as stated on sidewall, although we usually had them about 5psi below max to reduce bounce when towing. With our LT tires and our class A tires we can choose to use actual weights, that being said we still air them up regardless of weight about 5-10psi below max, that way our tires have plenty of load carrying capacity while reducing the harsh ride that max filled tires can present. Never had a blowout or catastrophic tire failure while RVing, and yes we have been over the 65mph threshold here and there pretty much every trip. If your 5er has ST tires best to fill to or near max psi for best performance, LT tires can be filled to only handle actual weight of rig, again we fill close to max psi for added weight carrying capacity.