As far as banking is concerned just make sure they have a nationwide presence, online access to ALL your accounts, you switch all your statements and correspondence to electronic. We don’t and never will fulltime but want anytime anywhere access to banking services. If you don’t already, and you take maintenance drugs you should switch to a nationwide pharmacy as you can get your drugs anywhere. Doesn’t work for controlled ones though.
I have heard that full timers without a permanent address can run into issues getting insurance, loans, other items. Not their doing.