Heading to Fla panhandle (Santa Rosa) from central MD in a few weeks, finalizing the route. Have taken 95 to Eastern Fla and other points North several times. 95 for me is a bit of a nightmare to star...
Don't forget, the part of I-81 between I-64 and Bristol has one of the highest accident rates in the country as a consequence of too many vehicles and too little pavement.