rvhunting - I tend to agree with "happyjack2" that the engine and transmission is not nearly as stressed with these short Class C's. A lot of miles do not have to be a death knell, however. If a mechanic of your choosing could do a compression test, it would give you a vote of confidence in the condition of the insides. Checking for oil leaks would be another valuable indication. The transmission fluid could be analyzed by a testing lab to indicate unusual happenings. The balance of the mechanicals are more routine maintenance items like brakes, hoses, belts, batteries, alternators, starters etc. A couple tests by a good mechanic can detect the difference between an engine about to give major problems and one that is still in solid condition.
I have seen some very high mileage internal combustion engines that just seem to run and run. I personally know of one two cylinder air cooled motorcycle with an excess of 500,000 miles that is still going strong.