1998 Winnebago Adventurer on the Ford F53 Chassis with E4OD transmission
61,000 miles
Purchased motorhome at 58,000 miles.
Two things happened, neither of which caused us to need a tow.
At about 59,000 miles noticed that the radiator side tank was seeping. Decided to do a full cooling system overhaul as preventative maintenance and did radiator, water pump, fan clutch, thermostat, all hoses, ignition tuneup, etc. When the water pump was pulled we found that a chip was broken off of the timing cover causing us to have to replace the timing cover and increasing the price of the work significantly. This could have been caused by poor cooling system maintenance (using tap water or not performing enough coolant changes over the years).
At 61,000 miles a tapping sound got much noisier and was determined to be a leaking exhaust manifold. What actually had occurred was that a piece of the head broke off due to manifold warping on the back driver side manifold. The head needed to be replaced entirely. Very expensive job took a month and a half to get our rig back. The manifold on the other side was cracked the whole way through but wasn't making any noticeable noise. Replaced this manifold too.
Everything *seems* to be running well now though.