I'll assume this is for a future trip. Border is still closed.
You're probably over thinking it.
Not knowing exactly (year/make/model) what you're driving or pulling, I would have the brakes, transmission, and cooling systems serviced before heading out, and change the engine oil before tackling any major uphill grades. As far as the actual driving, you'll figure it out. I find that down hill grades can be a little more challenging, and it's better to down shift early, than to risk losing control. 4-way flashers are a must when going much slower up hill and down.