Even if it snows, which is 50/50 going over the top, it will be fairly wet this time of year and the ground isn't frozen solid yet. So it will either be wet or slushy. The traffic is pretty heavy so there shouldn't be anything that extreme you can't pass in October.
Last Oct 12th (appox) I drove my MH over it and it snowed. Big wet flakes, no sticking.
I-70 is pretty steep in places, but east to west is just a lesson in patience as you will need to brake correctly. We do it a lot in our 40 footer with a Jeep in tow. No issues.
WW