US 160 is the only one I can help with. Wolf Creek Pass is much steeper traveling west to east. You will have about 10 miles of steep climb. But you will have two lanes going up so you can take your time without holding anyone up. And there are several pullouts if you need to pull off to cool down. Going down the east side is much less steep. But watch your speed as you approach the snow shed 2-3 miles down from the top. There is a curve going thru it and the speed limit needs to be observed.
After crossing the San Luis valley going toward Walsenberg you will cross North La Veta Pass. It is much steeper on the east side than the west. So going up shouldn’t be much problem, but you need to watch your speed, and brakes, going down.
Check the videos on US 550 between Ouray and Silverton to see what you will encounter there.