Like every idea in this life -it needs evaluation.
I used to be "spare parts freak" and always was carrying good spare.
On cars with limited service spare I even changed that to full service spare as driving 600 miles home at 55 mph can really suck.
But when I bought my conversion and start restoring it, I found that even storage bay fits 180lb spare just fine, Prevost has design space for it behind front bumper.
But than I learned more about those 22.5" tires, and they have about 2" of reinforced rubber on the crown and 3/4" of rubber on the side.
You need really big bolt to punch a hole in one and being commercial tires - having one blowing up is like winning a lottery.
Than I took the conversion on scales and found that even with lifted tag, my main axle tires still have carrying capacity to spare.
Meaning worse come to worse, I can put 2 blown wheels on tag axle and drive thousand miles with them lifted.
And yes, I still can mount 180lb wheel, although age takes its toll and I purchased AAA membership. (for DW)