There is basically no difference between driving a Class C and a big pick up truck but there are some considerations.
1: Larger sail space so if the conditions are windy.. You may have issues with handling and/or literally being blown off the road
2: Taller and wider may have problems with low hanging limbs or wires that in the summer do not hang so low.
3: Winterize water system I oike to use the DRY method for the fresh lines (Blow 'em out with compressed air 50 PSI several times with all valves open, hand drain the pump inlet strainer and run pump sans inlet cover for a minute after first blow,, Pink in drains, toilets and such)
Carry Jugged water (Jerry cans, Gallon jugs and such) inside RV for use.
Dump ASAP (your waste tanks)