On the V10 the plugs (and coils) all sit down in wells that surrounds the plug and coil. Ford sealed this hole from moisture and dirt with rubber/foam boot to protect the coil. Over time, heat from the engine cracks these boots and they deteriorate. Instead of keeping moisture and dirt out it seals it in around the plug and coil. New coils generally come with new boots. If you are changing plugs, it is a good practice to replace the boots at that time as they are probably past their prime. Use dielectric grease on the boots and they will last/seal much better.
Ford recommends a plug change at 100K miles but I follow the more practical interval of 75,000. If you wait until 100K you have a greater chance of the plug becoming one with the head or other extraction issues. It is cheap insurance to make sure you don't have a problem.