I run Full Sythetic when I'm towing, because I run pretty heavy (22,000 combined typically) and drive it pretty hard (Ave speed across the midwest is usually 85 MPH). But mostly because when I'm towing I'm putting on a lot of miles, which means 10-12,000 miles between oil changes.
When I'm not towing, I just run MotorCraft 5W-20 Synthetic blend, because not towing means more short trips, and I like to change it at 5,000 miles under those conditions.
I'm just shy of 373,000 miles. Still runs great!