With the popularity and the prime feature, I trust you're talking the ONAN 4KY series. Ours was made in 2002 and has about 450 hours. I don't use it often so it can be a couple weeks or more between uses. I prime it before the first start attempt. I only crank it for maybe 10 seconds. If it didn't start, I prime it again. I've gone to as many as three attempts but it always starts.
Don't get "priming guilt." You aren't squirting gas where it shouldn't be, or excess gas where it should be. All you're doing is running the fuel pump to make sure the carburetor's float bowl, where the engine gets it from anyway.
If your car (or RV!) has Fuel Injection, the pump prime the system by pressurizing it a pre-run the second you turn the key toward Start.
You'll put more load on the coach battery, and more wear and tear on the ONAN's starter, NOT priming it and waiting for the ONAN's fuel pump to catch up.
Just Prime It.