Have done it several times. Wishbone has some good suggestions. What you do, where you camp and how you travel is an individual thing, so it's hard to advise anyone. This is my style:
Almost never make reservations.
Prefer dry camping.
Don't use the city water hookups at RV parks but refill my fresh water tank frequently and filter my drinking water.
Prefer NFS, BLM & COE campgrounds but stay away from public parks on the weekends. (If you don't know why, you will)
Weekends are when I often stay in RV parks where I can get my laundry done, charge my electronics and maybe catch a ball game on TV.
Always make a detailed itinerary but usually ignore it. ;)
Have a wonderful trip!