Plan your route carefully, use AAA camping and sightseeing guides. Plan on enjoying the drive with frequent stops to relax and stretch your legs. 500 miles per day is about the max we want to do. Find places to stay overnight in the early evening before the no vacancy signs light up. Call ahead to reserve spots at nice RV parks. Avoid eating at restaurants to conserve money. Keep aware of bad weather ahead and alternative routes to avoid it. Allow plenty of time for an enjoyable round trip. Make sure that tires, engine cooling system brakes and house box electrical system, fridge and water heater, plumbing, roof and dash AC, furnace and generator are all in good order. Take your GPS, meds, personals, cameras and chargers, etc. Use GPS to help you through cities and highway transitions.
Drive safely especially in mountainous curvy stretches, don't drive faster than posted limits, pull over when it's safe and let impatient local yokels go by.