I77 From Columbia SC to Charleston WV

I do it several times a year with a 2006 34' Class A, F53 V-10, pulling a CRV. No drama up or down. Use the descent control on the trans,keep your foot of the brakes, your speed reasonable, and the downhill is actually quite pleasant, with some of the best scenery in the east. On the way up, the two biggest issues are idiot truckers holding snail drag races at 30 MPH, as they block a lane they shouldn't be in, and spend five minutes passing a truck that's going .001 MPH slower than they are. The other issue is being aware of what's happening far ahead, since you can be hammering along at 55+ and not realize that the truck lane and the next one to the left are full of trucks at a crawl. It's easy to end up stuck behind a few really slow rigs, while everybody else blows past, if your not watching the action as far forward as you can see.