First thing I'd do is have the motorhome weighed and then use tire weight/pressure chart to set the tire pressure based on the weight on the tire.
This usually winds up being more productive in the front, and some people go around with 20 plus PSI extra in front over need. Carrying excessive pressure will hurt the ride.
Otherwise, I don't know. I have the FSD shocks. I think they may have taken a bit of harshness out, but there is still some. Another poster here thinks they made a great improvement. I think the basic E450 rear leaf suspension has quite a bit of friction that transmits harshness. Perhaps some tires are better in this regard than others. Maybe very old tires have excessive stiffness.
I find my ride tolerable and quite good on good roads. On bad bumps it can be harsh, I slow down and get through it.