I have made two trips to Florida most winters in my Sunseeker Class C from northern NJ since 2013. There have been a couple of times where I have not dewinterized until there (it was single digits when departing - I'd have gotten frostbite on my fingers), but have successfully flushed the tank and piping as well as filled up with fresh water with the NJ weather at home an ambient 20 degrees but at least sunny. I do have the advantage of the water tank located within the house under the bed, and holding tanks enclosed above the chassis frame rails beneath the bedroom and bathroom floor(s).
Driving down the road, exhaust and rear axle heat will convect very well up through the floor, so no freezing issues at pretty much any east coast outside temp. When stopping overnight, I always have the goal of getting south enough to be above freezing. That hasn't always been the case, but with where my tanks are as well as running the house furnace, which has perforated ducts through the holding tank area, I've never had any issue even with temps in the low 20's.
I've also stuck a ceramic heater in the compartment where the water pump and low point drain plumbing is in super cold weather; there's an exterior 110v outlet not far away, routing the power cord through the door only latching one side, and run the generator overnight to blast the plumbing with heat. That arrangement I'd guesstimate would be good down to about 0 degrees in mine.