I-95 through SC and parts of the other states is so rough that it will surly test your coach to insure that everything is secure. The rough road also takes it's toll on the driver.
Drive until you feel TIRED and then look for a place to stop. Don't go by miles driven. There are plenty of RV parks along I-95 and we have always found a spot to spend the night, without any prior reservations.
Your first day you will have to deal with Philly, Baltimore, and DC. By the time you get past them, you will be ready to stop.