We moved from trailers (tag, toyhaulers, & 5vers) to a Class C moho last past summer. I enjoy traveling in a reasonably sized moho so much more than sitting behind the wheel of a pickup truck pulling a trailer (which I did for 20 years) it's no comparison for me.
I have no brand loyalty with cars, trucks, or RVs. I buy what will work for us / we like / & is available when we want or need the item. With that said, the Ford V-10 has a long-standing track record of being a reliable powerplant, the E-chassis has been made by the bushel basket for eons, & so what that amounts to is these guys are known & available.
Fuel average right about 10mpg traveling between 60-65.
The ONLY wish (not really a regret per se) is that our rig had a walk-around bed. We love the relative portability/simplicity of a 25ish ft coach with no slide for around traveling adventures. Makes it a lot easier to get away with stopping overnight in a parking lot / rest area etc.