Just another couple thoughts:
The vibration could also be a deteriorated motor mount, although I'm not sure why it would only do it at 45mph.
It may also be something in the spark system as mentioned. Had that happen on my 1992 Blazer once and I thought the whole thing was going to vibrate itself apart at a certain speed. Once past that speed it smoothed out. Finally found a crack in the distributor cap. I'm still learning about it, but I know the Triton V10 uses ignition coil packs on each spark plug, so you may have a bad coil pack or three....and/or bad wires causing the spark to go to ground instead of the plug. Could also be bad/cracked plugs. And I believe that year model also suffered from spark plug ejections due to a design flaw of not having enough plug threads in the block. So far, my 1999 is doing good....keeping my fingers crossed!
Let us know what you find out!