Assuming house batteries are in good shape and have 100% charge after running down the highway you should have plenty of hours of use before needing to charge them again.
Not knowing what your coach is or what your battery bank is it is hard to know whether you have 15 or 24 hours of battery life before getting to 50% depleted.
General answer is you never need to disconnect the house batteries until you put the coach in storage. I never turn mine off unless I am storing without a connection.