At age 60, I have taken the front tires off when replacing shocks. I was pleasantly surprised I could handle the tires quite well including lifting them, and I was never considered a well built guy. If I get a flat up front or in back, I really think changing one will be no big deal as long as I get the rig on a fairly flat surface. I have an advantage that my spare is easy to get to. It is stored inside the rear wall, behind an integrated tire cover as shown.

As far as a jack is concerned, the RV manufacture supplied a standard 6 ton bottle jack. I used the jack a few times to raise one pair of rear tires twice when I got into a pickle with my Lynx Levelers. The 6 ton nicely lifts either rear corner. A higher-rated jack would be harder for me to position under the rig and also be more weight and bulk in an already limited environment.

Regarding a tire iron. The RV came with the generic Ford-supplied tire iron. After reading stories of people unable to loosen their lug nuts with it, I bought an extra long 3/4" breaker bar, a 12" 3/4" extension, and a impact-rated 3/4" socket of the right lug nut size. This way I have confidence standing and even jumping on the breaker bar to get the lugs loose. If not for our rig, then for someone I am helping.

I also carry the shown emergency road-side tire repair kit. I keep this one in our tow vehicle.

I travel in comfort knowing I can take care of myself (and others), should a flat occur. We do travel most often to remote places.
With exception to the spare tire itself, everything is not a lot to carry. I would kick myself if I left any of it home and then found a need during a trip.