I had a 2000 V-10 in a 35 foot class A. Towed a Cherokee. CGVW was in the 25-26k pound range. Installed the Amsoil dual filter (regular filter plus a Bypass filter) at 7500 miles. Thereafter I changed the regular filter at 7500 miles and sent a sample for testing. I changed the Bypass filter every 25,000 miles. Between 35,000 and 45,000 miles I would get an oil analysis which recommended an oil change. At 127,000 the V-10 spit a plug and I had to pull the heads. Machine shop found no wear on the cams or valve stems.
An important point: the Bypass filter is a critical component of extended mileage oil changes. Without it I would change annually, or at the 15,000 mile point. Oil sampling is absolutely the best way to determine when to change oil. However, since the V-10 only holds 6 quarts the cost of an oil change is about the same as the cost of a sample analysis - less if you use a Fomoto valve and do it yourself. I currently have an 08 V-10 in a 28 foot class C. I plan to follow the annual or 15k mile change points.
I also agree that the V-10 is the best engine I've ever used -- well maybe not better than the old Volvo B-18 4 banger.