Unless you're looking to shake down your ride and a few years off its' life, do yourself a HUGE favor and don't take either one.
I ALWAYS, ALWAYS take 126 west to Ventura, then the 101 North and when you get near the south bay area, you have several options to cut over. Advantages are scenery, cooler temps in the summer, smoother roads and pure enjoyment! Of course this comes with extra fuel costs and additional time to drive it but as the saying goes, it's not just the destination it should always include the journey!