We have recently gone the other direction and moved from a long line of fifth wheels and trailers to a class "A". Unless you are looking at a 40" plus motor home you are more than likely going to find the fifth wheel a better option for long term stays. In our case however we will be doing more short term traveling (a month at the longest) and believe the ease of use, and enhanced ability to travel with our dogs along with not being saddled with the cumbersome gas consuming tow vehicle make a motor home a better choice.
I am sure there are times we will miss the fifth wheel though.